Maternal and perinatal brain aromatase: effects of dietary soy phytoestrogens.
نویسندگان
چکیده
Phytoestrogens are extensively investigated for their potential to prevent many hormone-dependent cancers and age-related diseases, however little is known about their effects in brain. Brain aromatase and plasma phytoestrogen levels were determined in Sprague-Dawley rats fed a phytoestrogen-rich diet during pregnancy/lactation. Ingested phytoestrogens cross the placenta and become concentrated in maternal milk as evident from high infantile plasma concentrations. Dietary phytoestrogens, however, do not alter brain aromatase during pregnancy/lactation or perinatal development.
منابع مشابه
Neurobehavioral effects of dietary soy phytoestrogens.
Phytoestrogens, plant-derived nonsteroidal estrogens found in high abundance in most soy food products, have been studied for their potential beneficial effects against hormone-dependent cancers and age-related diseases. However, little is known about the influence of phytoestrogens on the brain or behavior. This brief review describes mainly our own studies in rodents that have examined the in...
متن کاملThe phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function.
Estrogen is synthesized in the testis, both in Leydig cells and seminiferous epithelium, and its importance in spermatogenesis is highlighted by the phenotype of the aromatase knockout (ArKO) mouse. These mice are unable to synthesize endogenous estrogens. The males develop postmeiotic defects by 18 wk of age. We hypothesized that maintenance of spermatogenesis in younger animals may be mediate...
متن کاملReproductive effects of dietary soy phytoestrogens, genistein and equol on farmed female beluga, Huso huso
In this study, 54 five-year-old farmed female beluga at stage II of sexual maturation were treated with 0 (control), 0.2, 0.4, 0.8 and 1.6 g of dietary soy equol (EQ) and genistein (GE) per each kilogram (kg) of diet during a year. Blood samples were collected and ovarian biopsy was performed quarterly. Results showed that 64.4% of the Huso huso sexually matured at EQ 0.4 g/kg and reached stage...
متن کاملEffects of phytoestrogens on the ovarian and pituitary phenotypes of estrogen-deficient female aromatase knockout mice.
OBJECTIVE Dietary phytoestrogens are promoted as alternatives to synthetic estrogens for hormone therapy, however, their effects on the reproductive axis have not been exhaustively studied in vivo. Female aromatase knockout mouse (ArKO) mice are estrogen-free, anovulatory, and have a block in folliculogenesis, hemorrhagic cysts, and development of Sertoli cells within their ovaries. The purpose...
متن کاملThe effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells.
Dietary phytoestrogens have been reported to inhibit aromatase activity in placental microsomes, but the effects in the human endometrium are unknown. Aromatase, the rate-limiting enzyme in the conversion of androgens to estrogens, has recently been shown to be expressed in the endometrium of women with endometriosis and is thought to play a role in the pathophysiology of this disease. Therefor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Brain research. Developmental brain research
دوره 126 2 شماره
صفحات -
تاریخ انتشار 2001